PROVIRON (MESTEROLONE) 25 MG 50 TABS CLEAR LABS

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Proviron can improve potency and sexual interest and in some cases increase sperm count. Proviron has anti-estrogen activity, ideal in cure and after cure of steroids. Proviron also hardens muscles like Masteron does but not as anabolic.

  • Form: Oral
  • Molecule: Mesterolone
  • Concentration: 25mg/tabs
  • Presentation: 50 Tabs
  • Recommended dosage: 25 – 100mg/day
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Description

Can Proviron be taken during a course of steroids?

When to use Proviron and how many tablets/milligrams (doses and intake amount)

In a cycle with anabolic androgenic protective steroids Proviron, Proviron (Mesterolon / Mesterolon) is taken:

  • After the tenth day – one tablet ( 50mg Proviron / Mesterolone) divided into two doses – half in the morning and half in the evening.
  • After the twentieth – the dose is increased from one and a half to two tablets (50-100 mg of Mesterolone/Proviron).

The use of Proviron in a bad spermogram

Many men have the problem of a bad spermogram, congenital or as a result of an unhealthy lifestyle, and this product successfully helps to normalize this function. Often, the problem of pregnancy comes from a bad spermogram.

In fact, due to its extremely high binding affinity for plasma proteins such as SHBG, mesterolone can boost the potency of other steroids. In bodybuilding environments, Proviron is seen primarily to increase androgen levels during dieting or race preparation and as an anti-estrogen due to its ability to resist the aromatase enzyme.

History of Proviron (Mesterolone)

Proviron was developed in 1934. and is one of the oldest known anabolic androgenic steroids.The literature indicates that it is the first steroid introduced as a drug into clinical practice for the treatment of “hormonal diseases in men”. Mesterolone was developed at the same time as methyltestosterone (1935) and testosterone propionate (1937), which are now considered obsolete by today's standards. Regardless of its age, Proviron has a long history of clinical practice and remains widely used today. It is usually prescribed to men to treat physical and mental regression caused by insufficient androgen levels, as well as infertility (mestrolone increases sperm quality and quantity).

The use of mesterolone to promote fertility is perhaps one of the most controversial indications for this drug, given that anabolic androgenic steroids are commonly associated with infertility. Also, the use of mesterolone is often misunderstood by athletes. For athletic purposes, it is used because it is an effective androgen that provides minimal gonadotropin suppression, not because it increases luteinizing hormone production. The lack of gonadotropin suppression supports androgenic activity for sperm production. Androgens have a direct stimulating effect on spermatogenesis and also affect sperm transport and maturation by affecting the epididymis, vas deferens and seminal vesicles.

Mesterolone is manufactured and distributed exclusively by Bayer (formerly Schering) under the trade name Proviron and is sold in over 30 countries worldwide. Other well-known names for this drug are Mestoranum and Provironum from Bayer, Pluriviron (Asche, Germany), Vistimon (Jenepharm, Germany) and Restore (Brown & Burke, India).Mesterolone has never been approved for distribution in the United States, despite its efficacy and safety.

How Proviron is distributed (Proviron / Mesterolone)

Proviron is widely available in human medicine markets around the world. Today it is manufactured and distributed exclusively by Bayer, although it can also be found as a product under other names and from other manufacturers. It is mainly administered as a 25mg or 50mg tablet.

Structure and characteristics of Proviron (Proviron / Mesterolone)

Mesterolone is a modified form of dihydrotestosterone. It differs by adding a methyl group at carbon 1, which helps protect the hormone from liver metabolism when taken orally. The same structural modification is used for Primobolan® (methenolone) oral tablets.

First-position alkylation slows first-pass hepatic metabolism of the steroid, although less so than c-17 alpha alkylation. Mesterolone is stable enough to achieve adequate blood levels, although its overall bioavailability remains much lower than that of 17-alpha alkylated oral steroids. Mesterolone also has a very strong affinity for sex hormone binding globulin (SHBG). This action may allow less binding of other steroids to SHBG and their presence in an active (free) state.

Side effects (estrogen)

Mesterolone is not aromatized in the body and is not measurably estrogenic. Taking antiestrogens is not necessary and estrogenic side effects are unlikely.

In fact, mesterolone is thought to act as an anti-aromatase in the body, preventing or delaying the conversion of steroids to estrogen. The result is comparable to Arimidex, although weaker.Dihydrotestosterone and Masteron (2-methyl-dihydrotestosterone), for example, have been used successfully to treat breast cancer and gynecomastia due to their highly androgenic and potentially anti-estrogenic effects. It has also been suggested that nandrolone may further reduce aromatase activity in peripheral tissues, where it is more resistant to estrogen conversion (the most active site of nandrolone aromatization is the liver) .

The anti-estrogenic effect of these compounds is likely due to their ability to compete with other compounds to bind to the aromatase enzyme. When it binds to steroids, an inhibitory effect is achieved because it is temporarily blocked and does not interact with other hormones.

Side effects (androgens)

Proviron (Proviron / Mesterolone) is classified as an androgenic steroid. Androgenic side effects are possible, especially at high doses. They are expressed in: oily skin, acne, facial and body hair. Men with a genetic predisposition to hair loss (androgenic alopecia) may notice accelerated baldness.

Women should be aware of the potential virilizing effects of anabolic androgenic steroids. These include changes in tone of voice, menstrual irregularities, changes in skin structure, facial hair, and clitoral enlargement. Additionally, the 5-alpha reductase enzyme does not metabolize mesterolone, so its relative androgenicity is not affected by the use of finasteride and dutasteride.

Side effects (hepatotoxicity)

Proviron (Proviron/Mesterolone) is not a C-17 alpha alkyl anabolic steroid and is not known to have hepatotoxic effects. Liver toxicity is unlikely.

Side effects (cardiovascular)

Anabolic/androgenic steroids can adversely affect serum cholesterol. This includes a tendency to lower HDL (good) cholesterol and raise LDL (bad) cholesterol, which can shift the balance from HDL to LDL, which can increase the risk of atherosclerosis. The relative effect of anabolic/androgenic steroids on serum lipids depends on dose, route of administration (oral/injectable), type of steroid (aromatizing or non-aromatizing), and level of resistance to hepatic metabolism.

Mesterolone is a non-aromatizing oral androgen and is expected to have a serious negative effect on lipids. Studies show that taking 100mg of mestrolone daily in men with male hypogonadism for approximately 6 months shows a significant increase in total cholesterol (18.8%) and LDL cholesterol (65.2%). ), accompanied by a significant reduction in HDL cholesterol (-35.7%).

Mesterolone should not be used when the history requires the exclusion of cardiovascular risk factors.

To help reduce cardiovascular fatigue, it is advisable to maintain a cardio training program and reduce the intake of saturated fat, cholesterol and simple carbohydrates at all times during AAS. It is recommended to supplement the diet with fish oil (4 grams per day) and a natural cholesterol/antioxidant such as Lipid Stabil or a product with similar ingredients.

Side effects (testosterone suppression)

Proviron has a negligible effect on gonadotropins and serum testosterone. Studies indicate that when taken in moderate doses (150mg per day or less), there is no significant suppression of testosterone levels.However, in studies with higher doses (300mg per day or more), the steroid has been reported to severely suppress serum testosterone.
For more information on potential side effects, see the “Side Effects” section.

Application (men)

For the treatment of androgen deficiency, Proviron is usually given as 1 tablet (25 mg) three times a day at the start of treatment. Later in the treatment, a lower dose is maintained, which is usually 1 tablet (25 mg) once or twice a day. These doses are used to support male fertility, usually in combination with other medications such as injectable FSH (follicle-stimulating hormone). The usual dose for athletes is 50-150 mg per day. The drug is usually taken for the entire 6-12 week cycle.

Many bodybuilders prefer to use Proviron while dieting in the relief or race preparation phases. This is particularly useful when anabolic steroids such as Winstrol®, Anavar or Primobolan® are used alone as their androgenic activity is quite low. Here, Proviron helps regulate the androgen to estrogen ratio in favor of androgenic potentials, which promotes even better muscle hardening, supported by an increase in libido and the tendency to burn body fat. Proviron is also used to prevent gynecomastia when using aromatizing steroids, often in combination with 10-20 mg of Nolvadex (Nolvadex) daily.

Application (women)

Proviron is not approved for use by women. This drug is not recommended for women for bodybuilding and sports purposes due to its strong androgenic nature and tendency to virilizing side effects.

Some women find that using one 25mg tablet daily is effective enough to alter hormonal balance for better muscle definition and fat burning. Intake is generally limited to 4-5 weeks to reduce the risk of developing permanent virilizing side effects. Adding a 10mg or 20mg tablet of Nolvadex can be an even more effective combination to harden the muscles and create an environment in which the body is much more likely to burn body fat, especially in areas with problems for women, such as hips and thighs. However, women should be very careful when taking this medicine.

Discontinuation of aromatization with Mesterolone / Proviron, Proviron

Proviron stops the aromatization in its early stages and Nolvadex fights the symptoms.
Apart from interfering with the aromatization process, Proviron and other aspects appeal to bodybuilders. One of the most important is that it can significantly increase the testosterone potential in the body. Most of the testosterone in the human body (97-98%) is inactive because it is associated with globolin (SHBG) and albumin. However, when Proviron enters the body, it joins these proteins and more testosterone remains free. This helps improve performance and protein synthesis.

With Proviron, athletes increase the effect of steroids as androgen levels remain high and estrogen levels remain consistently low. This property of Proviron is particularly evident in preparation for competition, when dieting.

Proviron works well at a normal dose of 25mg. daily, but some athletes prefer to take 25 mg. in the morning and 25 mg. evening. And if 50 mg. Proviron is combined daily with 20 mg. Nolvadex estrogen aromatization is completely stopped.As a side effect, it can be mentioned that Proviron exerts a slight load on the liver, but in cases where the doses are not exceeded, there is no risk of serious problems. If in isolated cases frequent or prolonged erections occur, the dose should be reduced or treatment should be discontinued to avoid damage to the penis. In conclusion, it can be said that if you are taking anabolic steroids which easily aromatize estrogen, you should take Proviron to protect yourself from gynecomastia.

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