PRIMOBOLAN (METHENOLONE ACETATE)
Primobolan improves muscle relief, increases strength and helps burn subcutaneous fat. Side effects such as increased blood pressure and water retention are excluded.
Primobolan® is the trademark of the anabolic steroid methenolone acetate. This steroid is very similar in action to Primobolan® Depot (Methenolone Enanthate) except that it is intended for oral administration instead of injection. Methenolone acetate is not 17-alpha alkylated and is one of the few oral steroids with low liver toxicity. It also exhibits properties as a moderately effective anabolic steroid with low androgenic and non-estrogenic activity. It is mainly used in the relief phases, when the main objective is the cleanliness and firmness of the muscles.
History of Primobolan (Methenolone Acetate)
Methenolone was first described in 1960. Squibb introduced the drug (as methenolone acetate) to the United States in 1962. It was only recently distributed as a 20 mg tablet under the name Nibal®. East German pharmaceutical giant Schering (now Bayer) acquired the rights to the steroid the same year and began selling it under the name Primobolan.Nibal® was quickly pulled from the US market and never returned as a product. Schering currently owns the rights to manufacture and sell Methenolone Acetate and consumers primarily recognize it as a Bayer steroid.
Primobolan was still recognized as a European steroid in the 1960s and 1970s and was distributed in countries such as Germany, Austria, Belgium, France, Netherlands and Finland. Schering (now Bayer) has been producing Methenolone Acetate Injection (Methenolone Acetate) 20mg/ml oil-based since 1993 and discontinued this version. Although the mostly oral formulation is currently available, the injectable form of this steroid is more effective.
Primobolan is described as an anabolic steroid for building quality and lean muscle mass. It is used as a medicine to treat diseases related to weight loss after surgery, infection, atrophy, taking aggressive corticosteroids or malnutrition (in some cases in osteoporosis and sarcopenia). This steroid has been used to promote weight gain in premature babies without signs of toxicity or side effects. Among athletes, Primobolan is a favorite and is considered a strong, low androgenic and non-estrogenic anabolic steroid, which makes it highly preferred for building lean muscle without unwanted side effects.
Although Primobolan demonstrated a good clinical safety profile, Schering (now Bayer) withdrew the steroid in 2000. Dosages of 5mg or 25mg are still available. Currently, confirmed stock globally is distributed from Japan and South Africa under the Bayer brand.
How is Primobolan (methenolone acetate) distributed
All Bayer Primobolan forms contain 5mg, 25mg or 50mg methenolone acetate in one tablet. The composition and dosage of other brands may vary by country and manufacturer.
Structure and Characteristics of Primobolan (Primobolan / Methenolone Acetate)
Methenolone is a derivative of dihydrotestosterone. It contains an extra double bond between carbon atoms 1 and 2, which helps stabilize the 3-keto group and increases the anabolic properties of the steroid. Additionally, a 1-methyl group is added which protects the steroid from hepatic metabolism. Primobolan uses methenolone with an acetic acid ester attached to the 17-beta hydroxyl group to protect the steroid when taken orally. Studies have shown methenolone to be an effective oral anabolic steroid in the acetate and unesterified form.
Side effects (estrogen)
Methenolone is not aromatized in the body and is not measurably estrogenic. Estrogenic side effects are rare with the use of this steroid. Athletes susceptible to gynecomastia need not worry about its use. At the same time, no water retention is observed. The increase in muscle mass with the use of this steroid is expressed as pure, quality muscle mass, without the accompanying side effects typical of aromatization-prone steroids. Methenolone is extremely suitable for use in relief cycles where fat and water retention is particularly undesirable.
Side effects (androgens)
Although classified as an anabolic steroid, androgenic side effects are possible with the use of Primobolan (Primobolan). They are expressed in: oily skin, acne, facial and body hair.Men with a genetic predisposition to hair loss (androgenic alopecia) may notice accelerated baldness. Women should be aware of the potential virilizing effects of anabolic androgenic steroids. These include changes in tone of voice, menstrual irregularities, changes in skin structure, facial hair and enlargement of the clitoris.
Methenolone is a relatively weak steroid and strong androgenic side effects are usually only associated with the use of higher doses. Women often find Primobolan an acceptable choice in their workout regimens.
Side effects (hepatotoxicity)
Primobolan is not considered a hepatotoxic anabolic steroid. Liver damage is unlikely. Studies have not shown significant changes in hepatic stress markers when the steroid is given at therapeutic doses. Although unlikely, liver toxicity cannot be completely excluded, especially at high doses.
Side effects (cardiovascular)
Anabolic/androgenic steroids can adversely affect serum cholesterol. This includes a tendency to lower HDL (good) cholesterol and raise LDL (bad) cholesterol, which can shift the balance from HDL to LDL, which can increase the risk of atherosclerosis. The relative effect of anabolic/androgenic steroids on serum lipids depends on dose, route of administration (oral/injectable), type of steroid (aromatizing or non-aromatizing), and level of resistance to hepatic metabolism.
Anabolic androgenic steroids can also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, cause left ventricular hypertrophy, or generally potentially increase the risk of cardiovascular disease and myocardial infarction.
Primobolan (Primobolan) has a significantly greater effect on liver cholesterol management than testosterone or nandrolone due to its non-aromatizing nature, but much less effective than 17-alpha alkylated steroids. Due to the route of administration, oral methenolone acetate exhibits a stronger negative effect on lipids than the injectable form.
To help reduce cardiovascular fatigue, it is advisable to maintain a cardio training program and reduce the intake of saturated fat, cholesterol and simple carbohydrates at all times during AAS. It is recommended to supplement the diet with fish oil (4 grams per day) and a natural cholesterol/antioxidant such as Lipid Stabil or a product with similar ingredients.
Side effects (testosterone suppression)
All anabolic/androgenic steroids, when taken in sufficient doses to promote muscle growth, should suppress endogenous testosterone production. After stopping testosterone boosters, the body's natural testosterone levels are restored for a period of 1-4 months. Keep in mind that prolonged anabolic androgenic steroid abuse can cause secondary hypogonadotropic hypogonadism, which subsequently requires medical intervention.
Primobolan is generally reported to have little effect on endogenous testosterone production.However, this information only applies to the use of therapeutic doses (20-25 mg per day) and is not relevant to doses used for bodybuilding purposes. In one study, over 50% of patients taking 30-45mg daily of Primobolan (Primobolan) had a 15-65% drop in gonadotropin levels. If this steroid is used in moderate doses for less than 8 weeks, hormonal recovery should not last long.
Studies show that taking Primobolan as an oral anabolic steroid with food can reduce its absorption. This is due to the fat-soluble nature of steroid hormones, which tend to dissolve in undigested dietary fat, and is the reason for reduced absorption from the gastrointestinal tract. For maximum absorption, this steroid should be taken on an empty stomach.
Prescriptions for clinical use of Primobolan (Primobolan) indicate a maximum daily dose of 100-150 mg. Usual doses for bodybuilding and sports are 75-150mg per day for 6-8 weeks. Usually this period of intake is sufficient to achieve a noticeable effect, although the use of this steroid should not expect a significant increase in muscle mass. Primobolan is generally used as a mild anabolic steroid, especially in relief cycles.
Due to its mild nature, Primobolan is often combined by athletes with other steroids for a stronger effect. In such cases, the most commonly used dose is 50 to 100 mg per day. Non-aromatizing androgens such as Halotestin® or trenbolone are often added to relief phases. This steroid is also used in mass stacks.Athletes usually combine Primobolan with testosterone, Dianabol or Anadrol 50® for these purposes. Here, however, the benefits are often accompanied by some degree of water retention due to the addition of an estrogenic component, and also increases the risk of hepatotoxicity in combination with the latter two steroids.
Prescriptions for the clinical use of Primobolan in women do not specify different dosages. It is only reported that pregnant women or those about to become pregnant should not use this steroid. For bodybuilding and athletic purposes, female athletes generally tolerate 50-75mg per day very well, with no signs of virilizing symptoms.
Some women choose to combine Primobolan with other anabolic steroids such as Winstrol® or Oxandrolone, in an attempt to increase muscle building and cycle efficiency. Although both steroids are quite tolerable, the use of moderate doses is recommended. Excessive doses can cause virilizing side effects.